研究業績（原著論文、招待講演等）

2022年

● Sandra Somuah-Asante and Kazuichi Sakamoto(2022) Stress Buffering and Longevity Effects of Amber Extraction Caenorhabditis elegans (C. elegans),Molecules 2022, 27, 3858. Sandra Somuah-Asante and Kazuichi Sakamoto(2022) Stress Buffering and Longevity Effects of Amber Extract

●Yuening Luo, Siqi Zhou, Reiko Takeda, Kazuma Okazaki, Marie Sekita, Kazuichi Sakamoto(2022) Protective effect of amber extract on human dopaminergic cells model against 6-hydroxydopamine-induced neurotoxicity, Molecules, 27, 1817.

●坂本和一, 菅原賢也 (2022) サーチュイン 遺伝子の活性化に働く新規機能分子の探索,第5章第3節185-193 , 生物の寿命延長〜老化・長寿命の基礎研究最前線〜,（株）エヌ・ティー・エス, 2022.3.22

2021年

●Ayasa Ochiai, Mahmoud Ben Othman, Kazuichi Sakamoto (2021) Kaempferol ameliorates symptoms of metabolic syndrome by improving blood lipid profile and glucose tolerance, Bioscience, Biotechnology, and Biochemistry, 85(10):2169-2176.

●Zhou Siqi, Drira Riadh, Kazuichi Sakamoto (2021) Grape extract promoted α-MSH-induced melanogenesis in B16F10 melanoma cells, which was inverse to resveratrol, Molecules 26(19):5959.

●Yosuke Kato and Kazuichi Sakamoto (2021) Niclosamide affects intracellular TDP-43 distribution in motor neurons, activates mitophagy, and attenuates morphological changes under stress. Journal of Bioscience and Bioengineering.

●Erica Sogo, Zhou Siqi, Haruna Haeiwa, Reiko Takeda, Kazuma Okazaki, Marie Sekita, Takuya Yamamoto, Mikio Yamano, Kazuichi Sakamoto (2021) Amber Extract Reduces Lipid Content in Mature 3T3-L1 Adipocytes by Activating the Lipolysis Pathway. Molecules, 26(15):4630.

●Tian Yuan, Zhou Siqi, Reiko Takeda, Kazuma Okazaki, Marie Sekita, Kazuichi Sakamoto (2021) Anti-inflammatory activities of amber extract in lipopolysaccharide-induced RAW 264.7 macrophages, Biomedicine & Pharmacotherapy 141:111854.

●Luo Yuening, Zhou Siqi, Haruna Haeiwa, Reiko Takeda, Kazuma Okazaki, Marie Sekita, Takuya Yamamoto, Mikio Yamano, Kazuichi Sakamoto (2021) Role of amber extract in protecting SHSY5Y cells against amyloid β1-42-induced neurotoxicity. Biomedicine & Pharmacotherapy, 141:111804.

●D3の菅原君が行った博士後期課程の研究成果に対して専攻長表彰が授与されました。

●Kensuke Yasuda, Yuki Kubo, Hiroki Murata, Kazuichi Sakamoto (2021) Cortisol promotes stress tolerance via DAF-16 in Caenorhabditis elegans, Biochemistry and Biophysics Reports, 26:100961

●Zhou Siqi, Haruka Yotsumoto, Yuan Tian, Kazuichi Sakamoto (2021) α-Mangostin suppressed melanogenesis in B16F10 murine melanoma cells through GSK3β and ERK signaling pathway, Biochemistry and Biophysics Reports, 26:100949

2020年

●Zhou Siqi and Kazuichi Sakamoto (2020) Citric acid promoted melanin synthesis in B16F10 mouse melanoma cells, but inhibited it in human epidermal melanocytes and HMV-II melanoma cells via the GSK3β/β-catenin signaling pathway. PLOS ONE 15(12):e0243565.

●D3の菅原君が日本乳酸菌学会2020年度大会において行った研究発表に対して若手優秀発表賞が授与されました。

●Takaya Sugawara and Kazuichi Sakamoto (2020) Quercetin enhances motility in aged and heat-stressed Caenorhabditis elegans nematodes by modulating both HSF-1 activity, and insulin-like and p38-MAPK signalling, PLOS ONE, 15(9):e0238528

●Ensaka Naoko and Kazuichi Sakamoto (2020) α-Pinene odor exposure enhances heat stress tolerance through Daf-16 in Caenorhabditis elegans, Biochemical and Biophysical Research Communications, 6;528(4):726-731

●Lin Minhui, Zhou Siqi, Kazuichi Sakamoto (2020) Alpha Mangostin promotes myogenic differentiation of C2C12 mouse myoblast cells, Biochemical and Biophysical Research Communications, 12;528(1):193-198

●Mahmoud Ben Othman and Kazuichi Sakamoto (2020) Effect of Inactivated Bifidobacterium Longum Intake on Obese Diabetes Model Mice (TSOD), Food Research International, 129:108792

●Raoua Jemai, Riadh Drira, Mohamed Makni, Hamadi Fetoui, Kazuichi Sakamoto (2020) Colocynth (Citrullus colocynthis) seed extracts attenuate adipogenesis by down-regulating PPARγ/SREBP-1c and C/EBPα in 3T3-L1 cells. Food Bioscience 33:100491

2019年

●D2の菅原君が第12回国際大学院生アカデミックフォーラムにおいて行った研究発表に対して口頭プレゼンテーション賞(Second Prize)が授与されました。

●D2の菅原君が線虫研究の未来を創る会2019において行った研究発表に対して優秀口頭発表賞が授与されました。

●Kensuke Yasuda and Kazuichi Sakamoto (2019) Oxytocin promotes heat stress tolerance via insulin signals in Caenorhabditis elegans, Bioscience, biotechnology, and biochemistry, 83(10):1858-1866

●Takaya Sugawara, Tsubasa Furuhashi, Kenji Shibata, Masayuki Abe, Keita Kikuchi, Masato Arai, Kazuichi Sakamoto (2019) Fermented product of rice with Lactobacillus kefiranofaciens induces anti-aging effects and heat stress tolerance in nematodes via DAF-16, Bioscience, biotechnology, and biochemistry, 83(8) 1-6

●D3の周君が行った博士後期課程の研究成果に対して専攻長表彰が授与されました。

●Takaya Sugawara, Danaporn Saraprug, Kazuichi Sakamoto (2019) Soy sauce increased the oxidative stress tolerance of nematode via p38 MAPK pathway, Bioscience, biotechnology, and biochemistry, 83(4) 1-8

2018年

●Zhou Siqi and Kazuichi Sakamoto (2018) Pyruvic acid/ethyl pyruvate inhibits melanogenesis in B16F10 melanoma cells through PI3K/AKT, GSK3β, and ROS‐ERK signaling pathways, Genes to Cells, 24(1) 60-69

●D1の菅原君が第11回日中韓大学院生フォーラムにおいて行った研究発表に対して口頭プレゼンテーション賞(金賞)が授与されました。

●Naoko Hirano and Kazuichi Sakamoto (2018) Linalool odor stimulation improves heat stress tolerance and decreases fat accumulation in nematodes, Bioscience, biotechnology, and biochemistry, 83(1) 148-154

●Takaya Sugawara and Kazuichi Sakamoto (2018) Killed Bifidobacterium longum enhanced stress tolerance and prolonged life span of Caenorhabditis elegans via DAF-16, British Journal of Nutrition, 120(8) 872-880

●Raoua Jemai, Riadh Drira, Hamadi Fetoui, Mohamed Makni, Kazuichi Sakamoto (2018) Colocynth (Citrullus colocynthis) Flesh Extract Suppresses Adipogenesis by Down-Regulating Adipogenic Transcription Factors and Their Target Genes in 3T3-L1 Preadipocytes, Food and Nutrition Sciences, 9(08) 1014

●Nattapong Thammawong, Haruka Takahashi, Takaya Sugawara, Kazuichi Sakamoto (2018) α-Mangostin Promotes DAF-16-Mediated Thermotolerance in Caenorhabditis elegans, Food and Nutrition Sciences, 9(06) 693

●Keita Kikuchi, Mahmoud Ben Othman, Kazuichi Sakamoto (2018) Sterilized bifidobacteria suppressed fat accumulation and blood glucose level, Biochemical and biophysical research communications, 501(4) 1041-1047

2017年

●Chiho Kurino, Tsubasa Furuhashi, Kaori Sudoh, and Kazuichi Sakamoto (2017) Isoamyl alcohol odor promotes longevity and stress tolerance via DAF-16 in Caenorhabditis elegans, Biochemical and Biophysical Research Communications, 485, 395-399

●Takumi Satoh, Kazuichi Sakamoto (2017) Fermented Brown Sugar Residue Prolongs the Caenorhabditis elegans Lifespan via DAF-16, Food and Nutrition Sciences, 8, 851-860

●Jayarani F. Putri, Nashi Widodo, Kazuichi Sakamoto, Sunil C. Kaul, Renu Wadhwa (2017) Induction of senescence in cancer cells by 50-Aza-20-deoxycytidine: Bioinformatics and experimental insights to its targets, Computational Biology and Chemistry, 70, 49-55

●Kenta Sawa, Takumi Uematsu, Yusuke Korenaga, Ryuya Hirasawa, Masatoshi Kikuchi, Kyohei Murata, Jian Zhang, Xiaoqing Gai, Kazuichi Sakamoto, Tomoyuki Koyama and Takumi Satoh (2017) Krebs Cycle Intermediates Protective against Oxidative Stress by Modulating the Level of Reactive Oxygen Species in Neuronal HT22 Cells, Antioxidants 2017, 6(1), 21; doi:10.3390/antiox6010021

2016年

●Riadh Drira, Taku Matsumoto, Masashi Agawa, Kazuichi Sakamoto (2016) Ice plant (Mesembryanthemum crystallinum) extract promotes lipolysis in mouse 3T3-L1 adipocytes via extracellular signal-regulated kinase activation, Journal of Medicinal Food, 19, 274-280

●Riadh DRIRA and Kazuichi SAKAMOTO (2016) Sakuranetin induces melanogenesis in B16BL6 murine melanoma cells through inhibition of ERK and PI3K/AKT signaling pathways, Phytotherapy Research, 30, 997-1002

●Tsubasa Furuhashi and Kazuichi Sakamoto (2016) Central nervous system promotes thermotolerance via FoxO/DAF-16 activation through octopamine and acetylcholine signaling in Caenorhabditis elegans, Biochemical and Biophysical Research Communication, 472-, 114-117

●Tsubasa Furuhash, Masaji Matsunaga, Yuji Asaharai and Kazuichi Sakamoto (2016) L-arginine, an Active Component of Salmon Milt Nucleoprotein, promotes Thermotolerance via Sirtuin in Caenorhabditis elegans, Biochemical and Biophysical Research Communication, 472, 287-291

●Tsubasa Furuhashi and Kazuichi Sakamoto (2016) Regulation of AKT activity prevents autonomic nervous system imbalance, Physiology & Behavior, 168, 20-23

2015年

●Tsubasa Furuhashi and Kazuichi Sakamoto (2015) Heat Shock Factor 1 Prevents the Reduction in Thrashing Due to Heat Shock in Caenorhabditis elegans, Biochemical and Biophysical Research Communication, 462, 190-194

●Riadh DRIRA and Kazuichi SAKAMOTO (2015) Isosakuranetin, a 4′-O-methylated flavonoid, stimulates melanogenesis in B16BL6 murine melanoma cells, Life Sciences, 143, 43-49

2014年

●Tsubasa Furuhashi and Kazuichi Sakamoto (2014) FoxO/Daf-16 Restored Thrashing Movement Reduced by Heat Stress in Caenorhabditis elegans, Comparative Biochemistry & Physiology, Part B, 170, 26-32

●Ran Zhao and Kazuichi Sakamoto (2014) (–)-Epigallocatechingallate Interferes RANKL/RANK Signal Pathway and Induces Apoptosis during Osteoclastogenesis in RAW264 Cell, Food and Nutrition Sciences, 5, 107-116

2013年

●坂本和一（2013）「健康長寿に働く新規生理機能物質の探索と解析-長寿遺伝子と健康」アカデミックフォーラム-BioTech2013、東京ビッグサイト、2013,5,9

●坂本和一（2013）「健康長寿やアンチエイジングに関わる長寿遺伝子活性化物質の開発と機能解析」、茨城県産業支援機関等合同成果発表会、水戸市、2013,2,14

2012年

●坂本和一（2012）「健康長寿に働く生理機能分子の探索と解析-長寿遺伝子と健康」、第29回KSS健康フォーラム、東京都、2012,10,31

●Kazuichi Sakamoto (2012) Natural Bioactive Compounds Acting to Health and Youth–Longevity genes and health-, 60th Anniversary of Japan SriLanka Diplomatic Relations（日本スリランカ国交樹立60周年記念講演）, コロンボ、スリランカ、2012, 10, 27

●坂本和一（2012）「健康長寿に働く新規機能分子の探索と解析-長寿遺伝子と健康-」、BioJapan2012、東京ビッグサイト、2012,10,10

●Kazuichi Sakamoto, Riadh Drira and Shu Chen (2012) Oleuropein and hydroxytyrosol inhibited adipocyte differentiation in mouse 3T3-L1 cells, Polyphenols Communications, 26, 339-340

●Megumi Kurosu and Kazuichi Sakamoto (2012) Mesembryanthemum crystallinum extract suppressed the early differentiation of Mouse 3T3-L1 preadipocytes, Journal of Natural Pharmaceuticals, 2(4), 184-189

●Hiroyuki Hano and Kazuichi Sakamoto (2012) Physiological Effects of a Herbal Extracts Mixture Containing Acanthopanax senticosus Harms on the Development, Reproduction, and Lipid Metabolism of Caenorhabditis elegans, Journal of Natural Pharmaceuticals, 2(4), 173-178