研究業績（原著論文、招待講演等）

2019年

●Takaya Sugawara, Tsubasa Furuhashi, Kenji Shibata, Masayuki Abe, Keita Kikuchi, Masato Arai, Kazuichi Sakamoto (2019) Fermented product of rice with Lactobacillus kefiranofaciens induces anti-aging effects and heat stress tolerance in nematodes via DAF-16, Bioscience, biotechnology, and biochemistry, 1-6

●D3の周君が行った博士後期課程の研究成果に対して専攻長表彰が授与されました。

●Takaya Sugawara, Danaporn Saraprug, Kazuichi Sakamoto (2019) Soy sauce increased the oxidative stress tolerance of nematode via p38 MAPK pathway, Bioscience, biotechnology, and biochemistry, 83(4) 1-8

2018年

●Zhou Siqi and Kazuichi Sakamoto (2018) Pyruvic acid/ethyl pyruvate inhibits melanogenesis in B16F10 melanoma cells through PI3K/AKT, GSK3β, and ROS‐ERK signaling pathways, Genes to Cells, 24(1) 60-69

●D1の菅原君が第11回日中韓大学院生フォーラムにおいて行った研究発表に対して口頭プレゼンテーション賞(金賞)が授与されました。

●Naoko Hirano and Kazuichi Sakamoto (2018) Linalool odor stimulation improves heat stress tolerance and decreases fat accumulation in nematodes, Bioscience, biotechnology, and biochemistry, 83(1) 148-154

●Takaya Sugawara and Kazuichi Sakamoto (2018) Killed Bifidobacterium longum enhanced stress tolerance and prolonged life span of Caenorhabditis elegans via DAF-16, British Journal of Nutrition, 120(8) 872-880

●Raoua Jemai, Riadh Drira, Hamadi Fetoui, Mohamed Makni, Kazuichi Sakamoto (2018) Colocynth (Citrullus colocynthis) Flesh Extract Suppresses Adipogenesis by Down-Regulating Adipogenic Transcription Factors and Their Target Genes in 3T3-L1 Preadipocytes, Food and Nutrition Sciences, 9(08) 1014

●Nattapong Thammawong, Haruka Takahashi, Takaya Sugawara, Kazuichi Sakamoto (2018) α-Mangostin Promotes DAF-16-Mediated Thermotolerance in Caenorhabditis elegans, Food and Nutrition Sciences, 9(06) 693

●Keita Kikuchi, Mahmoud Ben Othman, Kazuichi Sakamoto (2018) Sterilized bifidobacteria suppressed fat accumulation and blood glucose level, Biochemical and biophysical research communications, 501(4) 1041-1047

2017年

●Chiho Kurino, Tsubasa Furuhashi, Kaori Sudoh, and Kazuichi Sakamoto (2017) Isoamyl alcohol odor promotes longevity and stress tolerance via DAF-16 in Caenorhabditis elegans, Biochemical and Biophysical Research Communications, 485, 395-399

●Takumi Satoh, Kazuichi Sakamoto (2017) Fermented Brown Sugar Residue Prolongs the Caenorhabditis elegans Lifespan via DAF-16, Food and Nutrition Sciences, 8, 851-860

●Jayarani F. Putri, Nashi Widodo, Kazuichi Sakamoto, Sunil C. Kaul, Renu Wadhwa (2017) Induction of senescence in cancer cells by 50-Aza-20-deoxycytidine: Bioinformatics and experimental insights to its targets, Computational Biology and Chemistry, 70, 49-55

●Kenta Sawa, Takumi Uematsu, Yusuke Korenaga, Ryuya Hirasawa, Masatoshi Kikuchi, Kyohei Murata, Jian Zhang, Xiaoqing Gai, Kazuichi Sakamoto, Tomoyuki Koyama and Takumi Satoh (2017) Krebs Cycle Intermediates Protective against Oxidative Stress by Modulating the Level of Reactive Oxygen Species in Neuronal HT22 Cells, Antioxidants 2017, 6(1), 21; doi:10.3390/antiox6010021

2016年

●Riadh Drira, Taku Matsumoto, Masashi Agawa, Kazuichi Sakamoto (2016) Ice plant (Mesembryanthemum crystallinum) extract promotes lipolysis in mouse 3T3-L1 adipocytes via extracellular signal-regulated kinase activation, Journal of Medicinal Food, 19, 274-280

●Riadh DRIRA and Kazuichi SAKAMOTO (2016) Sakuranetin induces melanogenesis in B16BL6 murine melanoma cells through inhibition of ERK and PI3K/AKT signaling pathways, Phytotherapy Research, 30, 997-1002

●Tsubasa Furuhashi and Kazuichi Sakamoto (2016) Central nervous system promotes thermotolerance via FoxO/DAF-16 activation through octopamine and acetylcholine signaling in Caenorhabditis elegans, Biochemical and Biophysical Research Communication, 472-, 114-117

●Tsubasa Furuhash, Masaji Matsunaga, Yuji Asaharai and Kazuichi Sakamoto (2016) L-arginine, an Active Component of Salmon Milt Nucleoprotein, promotes Thermotolerance via Sirtuin in Caenorhabditis elegans, Biochemical and Biophysical Research Communication, 472, 287-291

●Tsubasa Furuhashi and Kazuichi Sakamoto (2016) Regulation of AKT activity prevents autonomic nervous system imbalance, Physiology & Behavior, 168, 20-23

2015年

●Tsubasa Furuhashi and Kazuichi Sakamoto (2015) Heat Shock Factor 1 Prevents the Reduction in Thrashing Due to Heat Shock in Caenorhabditis elegans, Biochemical and Biophysical Research Communication, 462, 190-194

●Riadh DRIRA and Kazuichi SAKAMOTO (2015) Isosakuranetin, a 4′-O-methylated flavonoid, stimulates melanogenesis in B16BL6 murine melanoma cells, Life Sciences, 143, 43-49

2014年

●Tsubasa Furuhashi ･ Kazuichi Sakamoto (2014) FoxO/Daf-16 Restored Thrashing Movement Reduced by Heat Stress in Caenorhabditis elegans, Comparative Biochemistry & Physiology, Part B, 170, 26-32

●Ran Zhao and Kazuichi Sakamoto (2014) (–)-Epigallocatechingallate Interferes RANKL/RANK Signal Pathway and Induces Apoptosis during Osteoclastogenesis in RAW264 Cell, Food and Nutrition Sciences, 5, 107-116

2013年

●坂本和一（2013）「健康長寿に働く新規生理機能物質の探索と解析-長寿遺伝子と健康」アカデミックフォーラム-BioTech2013、東京ビッグサイト、2013,5,9

●坂本和一（2013）「健康長寿やアンチエイジングに関わる長寿遺伝子活性化物質の開発と機能解析」、茨城県産業支援機関等合同成果発表会、水戸市、2013,2,14

2012年

●坂本和一（2012）「健康長寿に働く生理機能分子の探索と解析-長寿遺伝子と健康」、第29回KSS健康フォーラム、東京都、2012,10,31

●Kazuichi Sakamoto (2012) Natural Bioactive Compounds Acting to Health and Youth–Longevity genes and health-, 60th Anniversary of Japan SriLanka Diplomatic Relations（日本スリランカ国交樹立60周年記念講演）, コロンボ、スリランカ、2012, 10, 27

●坂本和一（2012）「健康長寿に働く新規機能分子の探索と解析-長寿遺伝子と健康-」、BioJapan2012、東京ビッグサイト、2012,10,10

●Kazuichi Sakamoto, Riadh Drira and Shu Chen (2012) Oleuropein and hydroxytyrosol inhibited adipocyte differentiation in mouse 3T3-L1 cells, Polyphenols Communications, 26, 339-340

●Megumi Kurosu and Kazuichi Sakamoto (2012) Mesembryanthemum crystallinum extract suppressed the early differentiation of Mouse 3T3-L1 preadipocytes, Journal of Natural Pharmaceuticals, 2(4), 184-189

●Hiroyuki Hano and Kazuichi Sakamoto (2012) Physiological Effects of a Herbal Extracts Mixture Containing Acanthopanax senticosus Harms on the Development, Reproduction, and Lipid Metabolism of Caenorhabditis elegans, Journal of Natural Pharmaceuticals, 2(4), 173-178